CKiD Study Information

Study Design

The design of the CKiD study is a prospective, observational cohort of children with chronic kidney disease. Exposures will be measured at baseline and scheduled annual follow-up visits will permit the subsequent updating of the exposures in cohort participants. Outcomes will also be assessed at the annual visits and they include: measures of kidney function; neurocognitive function; markers of risk factors for cardiovascular disease; growth and other co-morbid conditions. The study will use the power of the cohort design with regularly scheduled visits at which markers of disease progression will be measured under standardized procedures. Levels and longitudinal changes in markers will constitute the primary outcomes. The study will collect data on clinical events with primary interest in ESRD and death. Such events will provide time-to-event data to determine heterogeneity of times to ESRD in children with mild to moderate chronic kidney disease.

Inclusion Criteria

Exclusion Criteria

Description of Study Population

The CKiD study population will include two cohorts. Cohort 1 586 racially and ethnically diverse children, age 1-16 years old with mildly to moderately impaired kidney function, defined by an estimated GFR between 30 and 90 ml/min|1.73m2 by the Schwartz formula (sGFR). Cohort 2 will include approximately 280 children with mildly impaired kidney function, defined as an estimated GFR between 45 and 90 by the updated Schwartz formula (eGFR).

Study Visit Schedule

The table below outlines the tests and measurements taken at each CKiD Study visit. Once a participant undergoes renal replacement therapy (dialysis or transplantation), a brief interview and chart review are performed annually.

study visit schedule

Repository Samples

The CKiD Study collects serum, plasma, urine, hair, nails and DNA samples during study visits.